Impact of Kinases on mucous membrane pemphigoid pathogenicity

This research project focuses on Mucous Membrane Pemphigoid (MMP), a rare autoimmune blistering disorder affecting mucous membranes, characterized by autoantibodies targeting structural proteins of the basal membrane zone, leading to chronic inflammation and significant morbidity. The primary aim of this study is to investigate the role of Janus kinases (JAK) in MMP, focusing on their impact on disease development, activity, and progression. Specific objectives include assessing the efficacy of various JAK inhibitors in ameliorating clinical manifestations of experimental MMP, comparing their effectiveness with existing treatments, and elucidating the mechanisms of action of JAK inhibitors in the context of MMP. Additionally, multi-omics analyses will be conducted to uncover molecular signatures associated with MMP, potentially leading to personalized treatment strategies and early diagnostic biomarkers. The research is expected to enhance understanding of autoimmune pre-diseases and contribute to the development of effective interventions for patients with MMP and similar conditions.