MD A10: Testing a new single chain variable fragment for pemphigus foliaceus in the human skin organ culture model
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are organ-specific autoimmune blistering diseases of the skin. They are characterized and caused by autoantibodies against the desmogleins (dsgs) 1 and/or 3. Binding of anti-dsg1/3-autoantibodies to target antigens in the skin disrupts adhesion between keratinocytes, resulting in intraepidermal blistering (acantholysis). Using the human skin organ culture (HSOC) model established in the Hundt lab and a new single chain variable fragment targeting dsg1 produced by the Hammers lab, we want to test its efficacy on causing split formation in the human skin. We hope to establish a new HSOC model for PF which will serve as a testing tool to establish future treatment options for PF. Hopefully, we will afterwards test different kinase inhibitors and their potential to inhibit split formation in our newly developed HSOC model for PF.
- Projects
- 1st Generation
- A: Defining Autoimmune Pre-Disease
- B: Targeting of Autoimmune Pre-Disease
- Associated projects
- MD projects
- Concluded Projects
- MDs
- MD A1 - Investigation of the influence of specific CDK inhibitors on neutrophil activation
- MD A2 - Conception of an anatomical expression of landscape of target antigens in autoimmune blistering dermatoses as markers for lesion formation
- MD A3 - Structural characterization of skin-directed autoantibodies and their interaction with the antigen to gain insights into autoimmune pre-disease
- MD A4 - Do interactions between AT1R autoantibodies derived from patients with systemic sclerosis and endothelial cells lead to endothelial dysfunction?
- MD A5 - Optimization and exploitation of a 3D model of human skin for translational use
- MD A6- To study vasculopathy in systemic sclerosis
- MD A7- Identification of autoantibodies contributing to the break of immunotolerance in immunization induced MMP mouse model
- MD A8- The role of AT1R antibodies and extracellular vesicles in mediating endothelial dysfunction in systemic sclerosis with pulmonary arterial hypertension
- MD A9- Impact of glycosylation on IgG4-induced signaling in neutrophils
- MD A10- Testing a new single chain variable fragment for pemphigus foliaceus in the human skin organ culture model
- MD A11- Impact of glycosylation on IgG3-induced signaling in neutrophiles
- MD A12- Screening for inhibitors to prevent keratinocytes dissoziation
- MD A13- Investigation of the local and systemic complement activation in bullous pemphigoid
- MD A14 - Impact of different subclasses on immune complex-induced signaling in neutrophils.
- MD A15 - Novel target antigens as inducers of autoimmunity of autoimmune bullous dermatoses
- MD A16 - Identification of the major epitope of the BP180 ectodomain recognized by serum IgA autoantibodies of patients with pemphigoid diseases –IgA autoantibodies as prognostic marker?
- MD A17 - Autoantibody-mediated effects on endothelial and immune cell signaling in systemic sclerosis
- MD A18 - Molecular and cellular characterization of pre-autoimmune effects induced by aging in mice
- MD B1 - Testing the effect of kinase inhibitors in the human skin organ culture model
- MD B2 - Cigarette smoking-induced autoantibodies
- MD B3 - Contribution of taurine, hypoxanthine, vitamin B5 and B6 in the pathomechanism of pemphigus vulgaris
- MD B4 - The influence of prednisolone treatment on split formation in the human skin organ culture model for pemphigus vulgaris
- MD B5 - Molecular characterization of the pre-autoimmune effects of Western diet in healthy mice
- PhDs
- Ass. projects
- Ass MDs
- MDs
- 2nd Generation
- 1st Generation
MD student
Principal Investigators
Mentor
