MD B3: Contribution of taurine, hypoxanthine, vitamin B5 and B6 in the pathomechanism of pemphigus vulgaris
Pemphigus vulgaris (PV) is an autoimmune skin blistering disease that is clinically characterized by mucocutaneous blistering and erosions, with a severe course and it is potentially a life-threatening disease. In the vast majority of cases, PV is caused by autoantibodies targeting desmoglein 3 and 1, developed in a T-cell dependent fashion. The study of the metabolomics and lipidomics in PV showed unique signatures when compared to healthy controls. Furthermore, there are distinct metabolite profiles in PV before and after immunosuppressive treatment, and those profiles after the therapy cluster closely to those of healthy controls. For example, the plasma concentration of pantothenic acid (vitamin B5) and pyridoxine (vitamin B6) in active PV are reduced, while after the treatment, the plasma levels increase to the level of healthy donors. In contrast, taurine and hypoxanthine concentrations in active PV are increased and they return to those observed in healthy controls. It is well known, that these four altered metabolite profiles are associated with inflammatory bowel disease and arthritis, and they play a role in wound healing in cell culture models.
We will investigate the impact of taurine, hypoxanthine, vitamins B5 and B6 on (i) T cell activation, (ii) B cell activation, and (iii) we will determine if they modulate PV-IgG-induced pathogenic changes in keratinocytes and in a human skin organ culture model of pemphigus.
- Projects
- 1st Generation
- A: Defining Autoimmune Pre-Disease
- B: Targeting of Autoimmune Pre-Disease
- Associated projects
- MD projects
- Concluded Projects
- MDs
- MD A1 - Investigation of the influence of specific CDK inhibitors on neutrophil activation
- MD A2 - Conception of an anatomical expression of landscape of target antigens in autoimmune blistering dermatoses as markers for lesion formation
- MD A3 - Structural characterization of skin-directed autoantibodies and their interaction with the antigen to gain insights into autoimmune pre-disease
- MD A4 - Do interactions between AT1R autoantibodies derived from patients with systemic sclerosis and endothelial cells lead to endothelial dysfunction?
- MD A5 - Optimization and exploitation of a 3D model of human skin for translational use
- MD A6- To study vasculopathy in systemic sclerosis
- MD A7- Identification of autoantibodies contributing to the break of immunotolerance in immunization induced MMP mouse model
- MD A8- The role of AT1R antibodies and extracellular vesicles in mediating endothelial dysfunction in systemic sclerosis with pulmonary arterial hypertension
- MD A9- Impact of glycosylation on IgG4-induced signaling in neutrophils
- MD A10- Testing a new single chain variable fragment for pemphigus foliaceus in the human skin organ culture model
- MD A11- Impact of glycosylation on IgG3-induced signaling in neutrophiles
- MD A12- Screening for inhibitors to prevent keratinocytes dissoziation
- MD A13- Investigation of the local and systemic complement activation in bullous pemphigoid
- MD A14 - Impact of different subclasses on immune complex-induced signaling in neutrophils.
- MD A15 - Novel target antigens as inducers of autoimmunity of autoimmune bullous dermatoses
- MD A16 - Identification of the major epitope of the BP180 ectodomain recognized by serum IgA autoantibodies of patients with pemphigoid diseases –IgA autoantibodies as prognostic marker?
- MD A17 - Autoantibody-mediated effects on endothelial and immune cell signaling in systemic sclerosis
- MD A18 - Molecular and cellular characterization of pre-autoimmune effects induced by aging in mice
- MD B1 - Testing the effect of kinase inhibitors in the human skin organ culture model
- MD B2 - Cigarette smoking-induced autoantibodies
- MD B3 - Contribution of taurine, hypoxanthine, vitamin B5 and B6 in the pathomechanism of pemphigus vulgaris
- MD B4 - The influence of prednisolone treatment on split formation in the human skin organ culture model for pemphigus vulgaris
- MD B5 - Molecular characterization of the pre-autoimmune effects of Western diet in healthy mice
- PhDs
- Ass. projects
- Ass MDs
- MDs
- 2nd Generation
- 1st Generation