MD A11: Impact of glycosylation on IgG3-induced signaling in neutrophiles
Epidermolysis bullosa aquisita (EBA) is an autoimmune, subepidermal blistering disease which belongs to the group of pemphigoid diseases. The underlying pathomechanism is the binding of autoantibodies (mainly IgG) to collagen type VII, a major component of the anchoring fibrils of the dermal-epidermal junction (DEJ). The formation of the immune complex (IC) leads to activation of immune cells, especially neutrophils resulting in the release of reactive oxygen species (ROS) and proteases. This directly contributes to split formation in the DEJ. Importantly, not all ICs activate the neutrophils in the same way. The affinity is modulated by subclass and glycosylation pattern of the IgG antibodies.
Therefore, the overarching goal of the project is to identify kinase signatures and cellular functions in neutrophils activated with different IgG subclasses containing different glycoforms. Specifically, my project aims to investigate the function of differentially glycosylated IgG3 ICs.
- Projects
- 1st Generation
- A: Defining Autoimmune Pre-Disease
- B: Targeting of Autoimmune Pre-Disease
- Associated projects
- MD projects
- Concluded Projects
- MDs
- MD A1 - Investigation of the influence of specific CDK inhibitors on neutrophil activation
- MD A2 - Conception of an anatomical expression of landscape of target antigens in autoimmune blistering dermatoses as markers for lesion formation
- MD A3 - Structural characterization of skin-directed autoantibodies and their interaction with the antigen to gain insights into autoimmune pre-disease
- MD A4 - Do interactions between AT1R autoantibodies derived from patients with systemic sclerosis and endothelial cells lead to endothelial dysfunction?
- MD A5 - Optimization and exploitation of a 3D model of human skin for translational use
- MD A6- To study vasculopathy in systemic sclerosis
- MD A7- Identification of autoantibodies contributing to the break of immunotolerance in immunization induced MMP mouse model
- MD A8- The role of AT1R antibodies and extracellular vesicles in mediating endothelial dysfunction in systemic sclerosis with pulmonary arterial hypertension
- MD A9- Impact of glycosylation on IgG4-induced signaling in neutrophils
- MD A10- Testing a new single chain variable fragment for pemphigus foliaceus in the human skin organ culture model
- MD A11- Impact of glycosylation on IgG3-induced signaling in neutrophiles
- MD A12- Screening for inhibitors to prevent keratinocytes dissoziation
- MD A13- Investigation of the local and systemic complement activation in bullous pemphigoid
- MD A14 - Impact of different subclasses on immune complex-induced signaling in neutrophils.
- MD A15 - Novel target antigens as inducers of autoimmunity of autoimmune bullous dermatoses
- MD A16 - Identification of the major epitope of the BP180 ectodomain recognized by serum IgA autoantibodies of patients with pemphigoid diseases –IgA autoantibodies as prognostic marker?
- MD A17 - Autoantibody-mediated effects on endothelial and immune cell signaling in systemic sclerosis
- MD A18 - Molecular and cellular characterization of pre-autoimmune effects induced by aging in mice
- MD B1 - Testing the effect of kinase inhibitors in the human skin organ culture model
- MD B2 - Cigarette smoking-induced autoantibodies
- MD B3 - Contribution of taurine, hypoxanthine, vitamin B5 and B6 in the pathomechanism of pemphigus vulgaris
- MD B4 - The influence of prednisolone treatment on split formation in the human skin organ culture model for pemphigus vulgaris
- MD B5 - Molecular characterization of the pre-autoimmune effects of Western diet in healthy mice
- MD B6 - Testing the effect of kinase inhibitors in the human skin organ culture model for pemphigus foliaceus
- MD B7 - Testing the Effect of Kinase Inhibitors in the Human Skin Organ Culture (HSOC) Model for Pemphigus Foliaceus
- PhDs
- Ass. projects
- Ass MDs
- MDs
- 2nd Generation
- 1st Generation
MD student
Principal Investigators
Mentor
