MD A18: Molecular and cellular characterization of pre-autoimmune effects induced by aging in mice
Autoimmune diseases are a major clinical burden, affecting more than 5 % of the world-wide population. While treatment is only applied upon clinical disease manifestation, autoimmune diseases develop over years. However, screening for autoimmune pre-disease is far from being clinical routine due to the lack of definitive biomarkers. Several factors might influence the progression to overt autoimmune disease. Next to genetics, microbiota and environmental factors, aging is increasingly recognized as a potential modulator of immune function and inflammation, both of which are in involved in autoimmune processes.
My project aims to identify cellular and molecular changes in plasma, kidney, pancreas and liver of healthy young and old mice to investigate how aging contributes to the formation of autoantibodies and the outbreak of multiple autoimmune diseases.
To get a deeper insight into inflammatory changes in aging mice, plasma of 18-month-old mice and 1-month-old mice will be analyzed for different inflammatory markers and signs of autoimmunity. We will also analyze for IgM deposition in kidneys and confirm the development of autoimmune pancreatitis by performing immunostaining methods.
Understanding of early pre-autoimmune mechanisms may help us find key factors in the transition from health to autoimmunity in the elderly. If sensitive and specific biomarkers for autoimmune pre-disease could be identified, early detection and possibly even prevention of the clinical manifestation of the disease by therapy modulating the destructive process or antibody production before the onset of clinical symptoms could be possible.
- Projects
- 1st Generation
- A: Defining Autoimmune Pre-Disease
- B: Targeting of Autoimmune Pre-Disease
- Associated projects
- MD projects
- Concluded Projects
- MDs
- MD A1 - Investigation of the influence of specific CDK inhibitors on neutrophil activation
- MD A2 - Conception of an anatomical expression of landscape of target antigens in autoimmune blistering dermatoses as markers for lesion formation
- MD A3 - Structural characterization of skin-directed autoantibodies and their interaction with the antigen to gain insights into autoimmune pre-disease
- MD A4 - Do interactions between AT1R autoantibodies derived from patients with systemic sclerosis and endothelial cells lead to endothelial dysfunction?
- MD A5 - Optimization and exploitation of a 3D model of human skin for translational use
- MD A6- To study vasculopathy in systemic sclerosis
- MD A7- Identification of autoantibodies contributing to the break of immunotolerance in immunization induced MMP mouse model
- MD A8- The role of AT1R antibodies and extracellular vesicles in mediating endothelial dysfunction in systemic sclerosis with pulmonary arterial hypertension
- MD A9- Impact of glycosylation on IgG4-induced signaling in neutrophils
- MD A10- Testing a new single chain variable fragment for pemphigus foliaceus in the human skin organ culture model
- MD A11- Impact of glycosylation on IgG3-induced signaling in neutrophiles
- MD A12- Screening for inhibitors to prevent keratinocytes dissoziation
- MD A13- Investigation of the local and systemic complement activation in bullous pemphigoid
- MD A14 - Impact of different subclasses on immune complex-induced signaling in neutrophils.
- MD A15 - Novel target antigens as inducers of autoimmunity of autoimmune bullous dermatoses
- MD A16 - Identification of the major epitope of the BP180 ectodomain recognized by serum IgA autoantibodies of patients with pemphigoid diseases –IgA autoantibodies as prognostic marker?
- MD A17 - Autoantibody-mediated effects on endothelial and immune cell signaling in systemic sclerosis
- MD A18 - Molecular and cellular characterization of pre-autoimmune effects induced by aging in mice
- MD B1 - Testing the effect of kinase inhibitors in the human skin organ culture model
- MD B2 - Cigarette smoking-induced autoantibodies
- MD B3 - Contribution of taurine, hypoxanthine, vitamin B5 and B6 in the pathomechanism of pemphigus vulgaris
- MD B4 - The influence of prednisolone treatment on split formation in the human skin organ culture model for pemphigus vulgaris
- MD B5 - Molecular characterization of the pre-autoimmune effects of Western diet in healthy mice
- MD B6 - Testing the effect of kinase inhibitors in the human skin organ culture model for pemphigus foliaceus
- MD B7 - Testing the Effect of Kinase Inhibitors in the Human Skin Organ Culture (HSOC) Model for Pemphigus Foliaceus
- PhDs
- Ass. projects
- Ass MDs
- MDs
- 2nd Generation
- 1st Generation
MD Student
Principal Investigators
Mentor
